Amiloride-sensitive sodium channels

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia,

Year

1999

Language

English

Series

Current topics in membranes -- v. 47

Publisher

Academic Press

Editions

1

Pages

384

ISBN

9780080585185

Data source: Wikidata