Clostridium difficile
K. Aktories · 2000
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About the book
Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics & epidemiology of Clostridium difficile & describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A & B which are the major virulence factors. The molecular biology, biochemistry, pharmacology & cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion & various signaling processes.
Book details
- Year
- 2000
- Language
- English
- Publisher
- Springer
- Editions
- 2
- Pages
- 143
- ISBN
- 9783540672913
Data source: Wikidata
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