Protein Quality Control in Neurodegenerative Diseases Research and Perspectives in Alzheimers Disease

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Year

2012

Publisher

Springer

Editions

1

Pages

135

ISBN

9783642279270

Data source: Wikidata